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KMID : 0369819920220020133
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Jorunal of Korean Pharmaceutical Sciences
1992 Volume.22 No. 2 p.133 ~ p.137
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Preparation and Dissolution Characteristics of the Compression - Coated Controlled Release Tablet Exhibiting Three - step Release
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김철수/Kim CS
권혁노/차봉진/권종원/양중익/민신홍/Kwon HL/Cha BJ/Kwon JW/Yang JI/Min SH
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Abstract
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A novel oral controlled release tablet which may offer more uniform drug level in the body than simple zero-order was developed. The tablet is composed of three layers; outer film layer, middle part compression-coated hydroxypropylmethylcellulose (HPMC) matrix layer, and inner core layer. Each layer contains nicardipine HCl as a model drug. In vitro dissolution test showed that the tablet released the drug in clear three steps; a rapid initial release, followed by a constant rate of release, and then a second phase of fast release of drug. The dissolution characteristics could be modified easily by changing the grade of HPMC, thickness of matrix layer, content of methylcellulose in matrix layer, content of active ingredient in each layer. The pH of dissolution medium did not affect the release profile. This three-step release system is expected to raise the blood concentration rapidly to effective level and to maintain effective blood level longer than simple slow-release systems.
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KEYWORD
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oral controlled release system, three-step release, compression coating, hydroxypropylmethylcellulose, nicardipine hydrochloride
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